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Fetal Effects Of Cracking Knuckles

  • Patient education: Polymyositis, dermatomyositis, and other forms of idiopathic inflammatory myopathy (Beyond the Basics).
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Polymyositis, dermatomyositis, and other forms of idiopathic inflammatory myopathy. IDIOPATHIC INFLAMMATORY MYOPATHIESThe idiopathic inflammatory myopathies are a group of diseases in which inflammation occurs in muscles and often in organs and tissues other than muscle. Included in this group are various conditions whose names contain the term “myositis,” which simply means muscle inflammation. All are thought to be due to immune system abnormalities leading to the development of inflammation in muscle and other tissues.

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These are rare disorders, together affecting only about 1 in 1. More women than men are affected. Although the peak age of onset is in the 5. The word “juvenile” is used in the name when a child is affected by myositis. Clinical manifestations — The main symptom that is common to the inflammatory myopathies is muscle weakness. Other symptoms that indicate involvement of body systems other than muscle can occur.

Muscle weakness — Typically patients develop painless weakness of the proximal muscles—the large muscle groups of the upper arms, thighs, neck, and trunk—in a symmetric pattern affecting both sides of the body. The smaller distal muscles of the hands, wrists, feet, and ankles are usually not affected. Patients may notice difficulty rising from a chair, climbing stairs, or performing tasks overhead such as reaching up to a high shelf, while grip strength remains normal. At times there may be mild muscle soreness. The weakness usually develops over several weeks to months. The throat and upper esophagus consist of muscle identical to the muscles that control voluntary movement. As a result of weakness in these muscles, some patients will develop difficulty swallowing or may aspirate food into the lungs, which can lead to pneumonia.

Skin changes — People with dermatomyositis often develop a rash or other changes in the skin. Sometimes the rash develops before muscle problems occur. In some cases, the rash of dermatomyositis appears, but muscle weakness never develops. Several types of rash may occur. Gottron’s papules are red, often scaly, bumps overlying the knuckles of the fingers (picture 1. A- B). It can worsen with exposure to ultraviolet light. The heliotrope sign is named for the heliotrope flower, which is violet- colored.

These patients may develop a cough and shortness of breath with exertion that ranges from mild symptoms to severe, progressive respiratory distress. Antisynthetase syndrome — This subgroup of patients all have one of a family of antibodies in their blood termed the anti- synthetase antibodies. Anti- Jo- 1 antibody is the most common and is found in about 2. This subgroup is characterized by rashes (particularly mechanic’s hands), interstitial lung disease, fever, arthritis, and Raynaud’s phenomenon (in which the fingers turn white on cold exposure) in addition to muscle disease.

Juvenile dermatomyositis — Children with inflammatory myopathy usually but not always have a dermatomyositis rash. They differ from adults most importantly in that painful calcium deposits can form on the skin and on the fibrous tissue that wraps around muscles, called fascia. Other systemic rheumatic diseases — When myositis accompanies scleroderma or systemic lupus, the myositis does not always cause symptoms. Some people have mild muscle weakness, while others have only abnormal blood muscle enzymes to indicate the presence of the disease. Cancer — People with inflammatory myopathies, especially adults with dermatomyositis who do not have anti- synthetase antibodies, have an increased risk of cancer.

This risk increases with age and involves the same common cancers that affect the general population, including cancer of the lung, breast, prostate, and ovaries. As a result, people with certain inflammatory myopathies may need more frequent or involved cancer screening than those without these conditions. Diagnosis — The diagnosis of the inflammatory myopathies involves a careful history, a thorough physical exam, and some blood tests. People who have these conditions often have muscle weakness and/or typical skin changes, and blood tests showing evidence of muscle damage or the presence of antibody markers that signal these diseases.

Nearly all patients with myositis will have elevation of creatine kinase (CK) levels. Many will have antinuclear antibodies (ANA) or one of the anti- synthetase antibodies in their blood. Some myositis patients however will be “serologically silent,” meaning they have no antibody markers. Guitar Hero 3 Wii Unlock All Songs.

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